However, no data on the concentrations in prostate tissue in humans is available. Therefore, the concentrations of isoflavones and lignans in plasma and prostatic tissues according to the prostate volume were compared to determine their possible effect on the benign prostatic growth. METHODS Fasting plasma and prostatic tissue specimens were acquired from 25 men over 50 years of age with similar normal dietary habits and no previous history of drug intake that could affect the isoflavones and lignans levels. Quantitative analysis of the isoflavones, specifically equol, daidzein and genistein and lignans, particularly enterodiol and enterolactone, was performed by gas chromatography-mass spectrometry. However, the mean prostatic concentration of genistein was significantly lower in the BPH group than in the control group
The phytosterols, particularly beta-sitosterol, are found in numerous plants and are anti-inflammatory, inhibiting the synthesis of prostaglandins. Beta-sitosterol has been shown to be useful in cases of BPH by helping to reduce the normally elevated levels of prostaglandins in these patients.
In each group of lesions with cribriform architecture benign, premalignant and malignant intraductal or infiltratingthere are situations in which histological classification of the lesion is difficult or impossible on routine stains.
Descriere Benign prostatic hyperplasia BPH is a nonmalignant enlargement of the prostate. Symptoms related to BPH are one of the most common problems in older men.
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The majority of men over the age of 60 are considered to have urinary symptoms attributable to BPH. The proliferative disorder resulting in BPH affects both the stromal and the epithelial portions of the prostate.
The enlarging prostate results in the progressive occlusion of the proximal urethra and can result in both obstructive and irritative urinary tract symptoms. The preferred medical treatment for many men with symptomatic benign prostatic hyperplasia is either an alpha-adrenergic-receptor antagonist alpha-blockerwhich reduces smooth-muscle tone in the prostate, and bladder neck, or a 5α-reductase inhibitor, which reduces prostate volume by inducing epithelial atrophy.
These drugs have side effects including:-dizziness, fatigue, hypotension, headache, insomnia, gynecomastia, and retrograde ejaculation. The use of plants and herbs for medicinal purposes phytotherapy including treatment of BPH symptoms has been growing steadily in most countries.
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Usage of plant extracts is common in many countries of the world and is increasing in the United States. Prostate volume by age 40 the United States their use has also markedly increased, they are readily available as nonprescription dietary supplements and are often recommended in "natural health food stores or books" for self treatment of BPH symptoms.
Prunus domestica, or European plum, is a small deciduous tree in the Rosaceae rose family that is an ancient domesticated species, known only in cultivation. It is now cultivated in temperate areas worldwide for its fruit.
Mechanism of action The bark contains three groups of active constituents: phytosterols including beta-sitosterolpentacyclic triterpenoids including ursolic and oleaic acids and ferulic esters of long-chain fatty alcohols including ferulic esters of docosanol and tetracosanol. The elimination of the excess blood and vasal congestion helps reduce the size of prostate adenomas.
The pentacyclic triterpenoids also help inhibit inflammation by blocking enzymatic activity.
They are effective anti-edema agents and also help increase the integrity of small veins and capillaries. The third active group, the ferulic esters of long-chain fatty acids, act by inhibiting the absorption and metabolism of cholesterol.
BPH and other cases of enlarged prostates are characterized by containing abnormally high levels of cholesterol.
Plant efficacy was determined by measuring the effects of the herb on numerous parameters, including dysuria, nycturia, frequent urination, abdominal heaviness, residual urine, voiding volume, prostate volume, and peak flow.
Consumption of P. Domestica resulted in significant amelioration of symptoms, reduction in prostate size, and clearance of bladder neck urethral obstruction.
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Different prostate volume by age 40 suggest that these phytochemicals appear to work synergistically to improve the symptoms of BPH.
However, the most bioactive phytochemicals in pygeum are the phytosterols. Therefore, these components of pygeum extract are believed to exert the most important therapeutic effect in the treatment of BPH.